Last update
5/11/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.3
USERS' SCORE
Good
Based on 2 Reviews
8.2
Supplement Facts
Serving Size: 1 Nugget
Amount Per Serving
%DV
Vitamin B12 (as methylcobalamin)
1000 mcg
41,667%
Top Medical Research Studies
9
We evaluated the effectiveness of intramuscular vitamin B12 in treating low back pain among 60 patients aged 18 to 65 with mechanical pain lasting at least six months.
In this double-blind, placebo-controlled study, both groups showed improvement in pain levels. However, those receiving B12 had a more significant reduction in pain and dependence on pain medication compared to the placebo group.
Overall, B12 appears to be a safe option for alleviating low back pain, helping to reduce discomfort and medication use for those without nutritional deficiencies.
In this double-blind, placebo-controlled study, both groups showed improvement in pain levels. However, those receiving B12 had a more significant reduction in pain and dependence on pain medication compared to the placebo group.
Overall, B12 appears to be a safe option for alleviating low back pain, helping to reduce discomfort and medication use for those without nutritional deficiencies.
Read More
9
We explored the effects of vitamin B12 treatment on a patient experiencing severe back pain, along with other symptoms associated with subacute combined degeneration (SCD) from prolonged vitamin B12 deficiency. This case involved a 49-year-old man who faced a year of worsening weakness, pain, and gait abnormalities.
Upon diagnosis, he began receiving intramuscular vitamin B12 injections. Remarkably, within weeks, we observed significant improvements in his pain levels and mobility. This underscores the importance of recognizing vitamin B12 deficiency early since it can lead to debilitating conditions but is often reversible through timely treatment.
Our findings highlight how addressing nutrient deficiencies can enhance overall health and well-being. In this specific case, vitamin B12 not only alleviated back pain but also restored functioning, improving quality of life for the patient.
Upon diagnosis, he began receiving intramuscular vitamin B12 injections. Remarkably, within weeks, we observed significant improvements in his pain levels and mobility. This underscores the importance of recognizing vitamin B12 deficiency early since it can lead to debilitating conditions but is often reversible through timely treatment.
Our findings highlight how addressing nutrient deficiencies can enhance overall health and well-being. In this specific case, vitamin B12 not only alleviated back pain but also restored functioning, improving quality of life for the patient.
Read More
8
B vitamins improve back pain relief
We explored how B vitamins, when combined with a reduced dose of diclofenac, could enhance pain relief for patients suffering from acute lumbar pain. In a controlled study of 123 participants, those receiving both B vitamins and diclofenac experienced significantly better outcomes compared to those taking diclofenac alone. Remarkably, more patients in the combination therapy group achieved total pain relief sooner, highlighting the potential benefits of B vitamins in reducing the required dosage of NSAIDs while still providing effective pain management.
Read More
Most Useful Reviews
7
Effective for pain
I consume it daily to prevent anaemia. The quality is excellent and the size is very small, making it easy to ingest. It appears to be effective for my back pain and stiff shoulders, so I intend to continue taking it.
Read More
6
Good for pain
I hope you arrive early! It seems to be beneficial for my back pain!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.3
- All Researches
9.5
We investigated the impact of a treatment combining mannitol and vitamin B on piriformis syndrome (PS), which is characterized by sciatic nerve entrapment. In a study involving 22 patients, participants received a five-day intravenous infusion of mannitol alongside a six-week regimen of vitamin B, including B1, B2, and B12.
Our observations highlighted significant improvements in clinical assessments, particularly in tenderness and pain levels assessed by various tests and scales. Notably, the Numeric Rating Scale demonstrated a marked reduction in pain at rest, at night, and during activities, which were all statistically significant. Additionally, the swelling around the sciatic nerve also showed a noteworthy decrease.
While vitamin B12 was part of this combination treatment, we must acknowledge that the study's focus on mannitol alongside the vitamins makes it challenging to isolate vitamin B12's specific effects on back pain alone.
Nevertheless, the results suggest that the combined approach might be a promising alternative for managing PS effectively.
Our observations highlighted significant improvements in clinical assessments, particularly in tenderness and pain levels assessed by various tests and scales. Notably, the Numeric Rating Scale demonstrated a marked reduction in pain at rest, at night, and during activities, which were all statistically significant. Additionally, the swelling around the sciatic nerve also showed a noteworthy decrease.
While vitamin B12 was part of this combination treatment, we must acknowledge that the study's focus on mannitol alongside the vitamins makes it challenging to isolate vitamin B12's specific effects on back pain alone.
Nevertheless, the results suggest that the combined approach might be a promising alternative for managing PS effectively.
Read More
9
We evaluated the effectiveness of intramuscular vitamin B12 in treating low back pain among 60 patients aged 18 to 65 with mechanical pain lasting at least six months.
In this double-blind, placebo-controlled study, both groups showed improvement in pain levels. However, those receiving B12 had a more significant reduction in pain and dependence on pain medication compared to the placebo group.
Overall, B12 appears to be a safe option for alleviating low back pain, helping to reduce discomfort and medication use for those without nutritional deficiencies.
In this double-blind, placebo-controlled study, both groups showed improvement in pain levels. However, those receiving B12 had a more significant reduction in pain and dependence on pain medication compared to the placebo group.
Overall, B12 appears to be a safe option for alleviating low back pain, helping to reduce discomfort and medication use for those without nutritional deficiencies.
Read More
9
Mixed results from vitamin treatment
We investigated the effectiveness of Dolo-Neurobion, a combination of vitamins B1, B6, and B12 along with an analgesic, for patients with acute lumbosacral pain. The treatment began with a parenteral application followed by oral dosing.
Out of 53 patients, we observed that 77.4% experienced good to excellent relief from their pain, while 15.1% noted moderate effects. There were no notable side effects, which makes this treatment a viable option for managing pain associated with intrapelvic organ issues.
Out of 53 patients, we observed that 77.4% experienced good to excellent relief from their pain, while 15.1% noted moderate effects. There were no notable side effects, which makes this treatment a viable option for managing pain associated with intrapelvic organ issues.
Read More
9
We explored the effects of vitamin B12 treatment on a patient experiencing severe back pain, along with other symptoms associated with subacute combined degeneration (SCD) from prolonged vitamin B12 deficiency. This case involved a 49-year-old man who faced a year of worsening weakness, pain, and gait abnormalities.
Upon diagnosis, he began receiving intramuscular vitamin B12 injections. Remarkably, within weeks, we observed significant improvements in his pain levels and mobility. This underscores the importance of recognizing vitamin B12 deficiency early since it can lead to debilitating conditions but is often reversible through timely treatment.
Our findings highlight how addressing nutrient deficiencies can enhance overall health and well-being. In this specific case, vitamin B12 not only alleviated back pain but also restored functioning, improving quality of life for the patient.
Upon diagnosis, he began receiving intramuscular vitamin B12 injections. Remarkably, within weeks, we observed significant improvements in his pain levels and mobility. This underscores the importance of recognizing vitamin B12 deficiency early since it can lead to debilitating conditions but is often reversible through timely treatment.
Our findings highlight how addressing nutrient deficiencies can enhance overall health and well-being. In this specific case, vitamin B12 not only alleviated back pain but also restored functioning, improving quality of life for the patient.
Read More
9
Gelatin sponge aids postoperative recovery
We conducted a study to understand if a "cocktail treatment," which includes a gelatin sponge soaked in ropivacaine, dexamethasone, and vitamin B12, could improve recovery after a procedure known as percutaneous endoscopic lumbar discectomy (PELD). This treatment aimed to address not just the mechanical issues of a herniated disc but also the inflammatory responses that often lead to prolonged pain.
Our research involved 100 patients who underwent PELD for single-level lumbar disc herniation. Half of them received the cocktail treatment, while the other half were given a gelatin sponge without any medication as a control group. We evaluated the outcomes based on pain relief and functional recovery, using tools like the Visual Analog Scale (VAS) for assessing back and leg pain and the Oswestry Disability Index (ODI) for measuring disability.
The inclusion of vitamin B12 in the cocktail treatment seems to promote earlier pain relief and functional recovery after surgery. However, because this treatment was mixed with other medications, it’s hard to isolate the specific effect of vitamin B12 on its own. While we saw positive results in terms of overall recovery, we can't definitively claim that vitamin B12 alone contributed significantly to alleviating back pain.
Our research involved 100 patients who underwent PELD for single-level lumbar disc herniation. Half of them received the cocktail treatment, while the other half were given a gelatin sponge without any medication as a control group. We evaluated the outcomes based on pain relief and functional recovery, using tools like the Visual Analog Scale (VAS) for assessing back and leg pain and the Oswestry Disability Index (ODI) for measuring disability.
The inclusion of vitamin B12 in the cocktail treatment seems to promote earlier pain relief and functional recovery after surgery. However, because this treatment was mixed with other medications, it’s hard to isolate the specific effect of vitamin B12 on its own. While we saw positive results in terms of overall recovery, we can't definitively claim that vitamin B12 alone contributed significantly to alleviating back pain.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7
Effective for pain
I consume it daily to prevent anaemia. The quality is excellent and the size is very small, making it easy to ingest. It appears to be effective for my back pain and stiff shoulders, so I intend to continue taking it.
Read More
6
Good for pain
I hope you arrive early! It seems to be beneficial for my back pain!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- He C, Li J, Hu W, Xiao B, Fan T, et al. Effects of dexamethasone combined with vitamin B12 on percutaneous endoscopic interlaminar discectomy early outcomes: a randomized controlled trial. J Orthop Surg Res. 2024;19:733. 10.1186/s13018-024-05210-z
- Mibielli MA, Geller M, Cohen JC, Goldberg SG, Cohen MT, et al. Diclofenac plus B vitamins versus diclofenac monotherapy in lumbago: the DOLOR study. Curr Med Res Opin. 2009;25:2589. 10.3111/13696990903246911
- Mauro GL, Martorana U, Cataldo P, Brancato G, Letizia G. Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci. 2000;4:53. PubMed
- Brüggemann G, Koehler CO, Koch EM. [Results of a double-blind study of diclofenac + vitamin B1, B6, B12 versus diclofenac in patients with acute pain of the lumbar vertebrae. A multicenter study]. Klin Wochenschr. 1990;68:116. PubMed
- Kuhlwein A, Meyer HJ, Koehler CO. [Reduced diclofenac administration by B vitamins: results of a randomized double-blind study with reduced daily doses of diclofenac (75 mg diclofenac versus 75 mg diclofenac plus B vitamins) in acute lumbar vertebral syndromes]. Klin Wochenschr. 1990;68:107. PubMed
- Kunt T. [Complaints in the lumbosacral region and their management with Dolo-Neurobion]. Fortschr Med. 1978;96:299. PubMed
- Demko AW, Rustom DH. Progressive Decrease in Function and Ambulation Potential: A Case of Subacute Combined Degeneration. Cureus. 2024;16:e64027. 10.7759/cureus.64027
- Li QD, Yang JS, Gong HL, Wei JM, Wang XF, et al. Can Additional Facet Joint Block Improve the Clinical Outcome of Kyphoplasty for Acute Osteoporotic Vertebral Compression Fractures?. Pain Physician. 2021;24:283. PubMed
- Mibielli MAN, Nunes CP, Goldberg H, Buchman L, Oliveira L, et al. Nucleotides Cytidine and Uridine Associated with Vitamin B12 vs B-Complex Vitamins in the Treatment of Low Back Pain: The NUBES Study. J Pain Res. 2020;13:2531. 10.2147/JPR.S277024
- Yang JS, Liu KX, Chu L, Chan YK, Fan H, et al. Cocktail Treatment with a Gelatin Sponge Impregnated with Ropivacaine, Dexamethasone, and Vitamin B12 Promotes Early Postoperative Recovery after Percutaneous Endoscopic Lumbar Discectomy: A Retrospective, Case-Controlled Study. Pain Physician. 2020;23:E211. PubMed
- Buesing S, Costa M, Schilling JM, Moeller-Bertram T. Vitamin B12 as a Treatment for Pain. Pain Physician. 2019;22:E45. PubMed
- Huang ZF, Lin BQ, Torsha TT, Dilshad S, Yang DS, et al. Effect of Mannitol plus Vitamins B in the management of patients with piriformis syndrome. J Back Musculoskelet Rehabil. 2019;32:329. 10.3233/BMR-170983
- Zhang M, Han W, Hu S, Xu H. Methylcobalamin: a potential vitamin of pain killer. Neural Plast. 2013;2013:424651. 10.1155/2013/424651
- Chiu CK, Low TH, Tey YS, Singh VA, Shong HK. The efficacy and safety of intramuscular injections of methylcobalamin in patients with chronic nonspecific low back pain: a randomised controlled trial. Singapore Med J. 2011;52:868. PubMed
- Mibielli MA, Nunes CP, Cohen JC, Scussel AB, Higashi R, et al. Treatment of acute, non-traumatic pain using a combination of diclofenac-cholestyramine, uridine triphosphate, cytidine monophosphate, and hydroxycobalamin. Proc West Pharmacol Soc. 2010;53:5. PubMed
- Jurna I. [Analgesic and analgesia-potentiating action of B vitamins]. Schmerz. 1998;12:136. PubMed
- Vetter G, Brüggemann G, Lettko M, Schwieger G, Asbach H, et al. [Shortening diclofenac therapy by B vitamins. Results of a randomized double-blind study, diclofenac 50 mg versus diclofenac 50 mg plus B vitamins, in painful spinal diseases with degenerative changes]. Z Rheumatol. 1988;47:351. PubMed
